Graduate Student (Ph.D program)
Dept of Neurological Sciences
Rush University Medical Center
1735 W. Harrison St,
Cohn Research Building, #336
Ph. No. (312)942-3167 (Office)
Welcome to my academic home page. I am a second year graduate student (Ph.
D program) at the Neurological Science Program in Rush University Medical
Center and am a member of Pahan lab since Aug, 2005. I had my MS in Zoology
from the University of Calcutta, India in 2004.
My research interest is focused on examining the causes and therapeutic
approaches of Parkinson’s disease, a neurodegenerative disorder. We induce
Parkinsonian symptoms and pathology in mice by administration of neurotoxin
MPTP. We test different pharmacological drugs as therapeutic agents to
investigate whether these drugs could reduce the activation of glial cells and
rescue the dopaminergic neurons in the substantia nigra. We have already
shown that NBD peptide, a specific inhibitor of NF-kB, enters into the brain, blocks
nigral activation of NF-kB, inhibits the activation of glial cells, and protects
dopaminergic neurons in the substantia nigra. Currently I am working on
neuroprotective effects of lipid lowering drugs like statins, sodium phenylbutyrate
etc. The goal of my research is to develop a deeper understanding of various
inflammatory mechanisms that are involved in Parkinson’s disease.
1.Ghosh, A., Roy, A., Liu, X., Kordower, J., Mufson, E., Hartley, D., Moseley, R.,
Gendelman, H., Ghosh, G., Pahan, K. (2007) Selective inhibition of NF-kB
activation prevents dopaminergic neuronal loss in a mouse model of Parkinson’s
disease. Proceedings of the National Academy of Sciences of Sciences of the
United States of America (PNAS) (In press).
2. Saha, R., Ghosh, A., Palencia, C., Fung, Y., Pahan, K. (2007) ;Neuron specific
CBP regulation is critical for tumor necrosis factor α-mediated neuronal
preconditioning. Journal of Neuroscience (Accepted).