Avik Roy,PhD

                                               Research Assistant Professor
                                               Pahan Lab

                                               1735 W Harrison Street
                                               Cohn Research Building # 336
                                               Rush University Medical Center
                                               Ph: (312)9423167
                                               Email: avik _roy@rush.edu

Received M.S. from the University of Calcutta in biochemistry (1999-2001) and
received Ph.D in Pahan lab ,Rush University (2004-2009).

Research interest
My area of research highlights microglial activation in different
neuroinflammatory diseases and a possible therapeutic approaches to modify
activated microglia towards its neuroprotective function. In neurodegenerative
condition, microglia  produce different proinflammatory cytokines and reactive
oxygen species which cause demyeliantion and finally,neuronal loss. On the
other hand, microglia can also produce a large amount of neurotrophic factors
such as BDNF, NT-3 etc. We have found that nitric oxide as one of the key
component which regulates microglia mediated neuroinflammation in brain.
Different proinflammatory molecules such as IFN-γ, TNF-α, IL-1β, HIV coat
protein gp120 etc and autoimmune T cells induce microglial activation via nitric
oxide. However, in our recent studies we showed that activated microglia could
be switched to produce different neuroprotective factors in the presence of drug-
modified autoimmune T cells.

Pahan Lab Members